皮下注射催乳素和20K人生长激素（hGH）可预防大鼠因束缚应激引起的胃溃疡，但重组人生长激素（rGH）或22K hGH则无此作用。

Subcutaneously administered prolactin and 20K hGH, but not rGH or 22K hGH, prevent restraint stress-induced gastric ulcers in rats.

作者信息

Fujikawa K, Fukuoka H, Alam K S, Yoshizato H, Higashimoto S, Soya H, Tanaka M, Nakashima K

机构信息

Department of Biochemistry, Mie University School of Medicine, Tsu, Japan.

出版信息

Endocr J. 2000 Mar;47 Suppl:S49-52. doi: 10.1507/endocrj.47.supplmarch_s49.

DOI:10.1507/endocrj.47.supplmarch_s49

PMID:10890183

Abstract

Stress causes gastric ulcer in vertebrates. In humans, growth hormone (hGH) and prolactin (hRPL) are promptly released into the circulation under the stress conditions, while in rats exposed to stress, the circulating levels of GH (rGH) are decreased and the circulating PRL (rPRL) levels are rapidly increased as in humans during stress. However, the roles of the circulating rGH and rPRL during stress are still unclear. Here we analyzed whether 22K hGH, 20K hGH or rGH, when compared to rPRL, can affect restraint stress in water (RSW)-induced gastric ulcers. Pretreatments of rats with subcutaneously (s.c.) administered rPRL or 20K hGH clearly prevented the development of the gastric injuries in rats subjected to 7 h RSW. The s.c. pretreatment with 22K hGH resulted in little cytoprotection in the rats exposed to RSW, while s.c. pretreatment with rGH showed no such protective effect against RSW-induced gastric injuries. Results suggested that rPRL and 20K hGH were acting on PRL receptor, but not on GH receptor, to prevent RSW-induced gastric injuries.

摘要

应激会导致脊椎动物患胃溃疡。在人类中，生长激素（hGH）和催乳素（hRPL）在应激条件下会迅速释放到循环系统中，而在遭受应激的大鼠中，生长激素（rGH）的循环水平会降低，催乳素（rPRL）的循环水平则会像人类在应激时一样迅速升高。然而，应激期间循环中的rGH和rPRL所起的作用仍不清楚。在此，我们分析了与rPRL相比，22K hGH、20K hGH或rGH是否会影响水浸束缚应激（RSW）诱导的胃溃疡。皮下（s.c.）注射rPRL或20K hGH预处理大鼠，可明显预防遭受7小时RSW的大鼠发生胃损伤。皮下注射22K hGH预处理对遭受RSW的大鼠几乎没有细胞保护作用，而皮下注射rGH预处理对RSW诱导的胃损伤没有这种保护作用。结果表明，rPRL和20K hGH是通过作用于催乳素受体而非生长激素受体来预防RSW诱导的胃损伤。