Sawan B, Vital A, Loiseau H, Dousset V, Strub D, Vital C
Laboratoire de Neuropathologie, Université Victor Ségalen-Bordeaux II, Bordeaux, France.
Ann Pathol. 2000 May;20(3):258-60.
Intracranial epidermoid cysts represent around 0,2 to 1 % of all intracranial tumours. Rare malignant transformation of these benign lesions may occur. A 66-year-old man presented with a state of confusion. MRI demonstrated a heterogeneous signal in front of the pons and ventricular dilatation. Cerebrospinal fluid examinations disclosed inflammatory cells. The patient died six months after his first admission to hospital. At autopsy, a firm greyish tumour (3 cm-long and 1 cm-thick) was present in front of the brain stem encasing the basilar artery. Microscopic examination revealed a well-differentiated epidermoid carcinoma arising from a cystic lesion whose wall was lined by a squamous epithelium with a benign appearance. The walls of all the ventricles were lined by carcinomatous cells. There was no leptomeningeal metastasis. Twenty three other cases of such squamous cell carcinoma have been reported and most of them had died within a few months.
颅内表皮样囊肿约占所有颅内肿瘤的0.2%至1%。这些良性病变可能会发生罕见的恶性转化。一名66岁男性出现意识模糊状态。磁共振成像（MRI）显示脑桥前方信号不均以及脑室扩张。脑脊液检查发现炎性细胞。该患者首次入院后6个月死亡。尸检时，在脑干前方有一个坚实的灰色肿瘤（长3厘米、厚1厘米），包绕着基底动脉。显微镜检查显示，一个囊性病变发生了高分化表皮样癌，其囊壁内衬外观良性的鳞状上皮。所有脑室壁均衬有癌细胞。无软脑膜转移。另外已报道了23例此类鳞状细胞癌病例，其中大多数在几个月内死亡。
