Neurology. 2000 Jul 12;55(1):66-73.
To estimate the incidence of dementia, including AD, among Canadians aged 65 and over.
A 5-year cohort study of 10,263 seniors was undertaken, including community and institutional samples. The baseline study in 1991 identified 1,132 prevalent cases of dementia through screening and clinical examination. The remaining 9,131 cases formed the incidence study sample and were rescreened and selectively reexamined in 1996. Incident cases were diagnosed using established criteria. Incidence was estimated based on the 1991 population, and included data on those who died between the first and second phases of the study.
Of the nondemented cohort who remained alive in 1996, 5,432 people in the community (88.3%) and 210 (91.3%) in the institutional sample participated in the incidence study. Nine hundred sixty incident cases were identified; the overall age-standardized incidence rates were 21.8 (women) and 19.1 (men) per 1,000 nondemented persons per year. This translates into 60,150 new cases of dementia per year in Canada. The logarithm of the rates rises linearly with age, but suggests a slight slowing of growth in incidence in the oldest age groups.
Our incidence estimates lie toward the upper end of the range of incidence estimates found in other studies. Nonetheless, we calculate that several factors may have biased our estimates downward, suggesting that the incidence of dementia may be higher than many studies have reported.
评估65岁及以上加拿大人群中包括阿尔茨海默病(AD)在内的痴呆症发病率。
对10263名老年人进行了一项为期5年的队列研究,包括社区和机构样本。1991年的基线研究通过筛查和临床检查确定了1132例痴呆症现患病例。其余9131例构成发病率研究样本,并于1996年进行了重新筛查和选择性复查。采用既定标准诊断新发病例。发病率根据1991年的人口数据进行估算,包括研究第一阶段和第二阶段之间死亡者的数据。
在1996年仍存活的非痴呆队列中,社区中有5432人(88.3%)、机构样本中有210人(91.3%)参与了发病率研究。共确定了960例新发病例;总体年龄标准化发病率为每1000名非痴呆者中女性每年21.8例、男性每年19.1例。这相当于加拿大每年有60150例新发痴呆症病例。发病率的对数值随年龄呈线性上升,但表明最年长者发病率的增长略有放缓。
我们的发病率估算值处于其他研究发现的发病率估算范围的上限。尽管如此,我们计算得出,有几个因素可能使我们的估算值偏低,这表明痴呆症的发病率可能高于许多研究报告的结果。