Karges W, Maier S, Schmidt F, Gress T M, Boehm B O
Department of Internal Medicine, Division of Endocrinology, University of Ulm, Robert Koch Strasse, Germany.
Cancer Lett. 2000 Aug 31;157(1):51-5. doi: 10.1016/s0304-3835(00)00471-7.
MEN1 is a novel tumour suppressor gene involved in the etiology of sporadic endocrine pancreatic tumours. Based on common ontogenetic features of both tissues, we analyzed the role of MEN1 in ductal pancreatic cancer. Wild type MEN1 mRNA expression, but no mutations within the MEN1 coding sequence or MEN1 promoter region were detected in human pancreatic adenocarcinoma tissues and carcinoma cell lines, using sensitive single-strand conformational polymorphism-heteroduplex and sequencing analyses. Thus, human pancreatic cancer does not seem to require inactivation of the MEN1 tumour suppressor pathway.
MEN1是一种参与散发性内分泌胰腺肿瘤病因学的新型肿瘤抑制基因。基于两种组织共同的个体发生特征，我们分析了MEN1在导管胰腺癌中的作用。使用灵敏的单链构象多态性-异源双链和测序分析，在人胰腺腺癌组织和癌细胞系中未检测到野生型MEN1 mRNA表达，但在MEN1编码序列或MEN1启动子区域内未发现突变。因此，人类胰腺癌似乎不需要MEN1肿瘤抑制途径的失活。
