Tang G, Jiang S, Zhang M, Lin S, Qian Y, Wu X, Wang D, Jin T, Gu N
Department of Genetics, Shanghai Institute of Mental Health, Shanghai, China.
Am J Med Genet. 2000 Apr 3;96(2):133-5. doi: 10.1002/(sici)1096-8628(20000403)96:2<133::aid-ajmg1>3.0.co;2-y.
We investigated a common signal peptide polymorphism in the alpha 1-antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Han population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:133-135, 2000.
我们在中国汉族人群的125例散发性阿尔茨海默病（AD）患者和141名健康对照者中，研究了α1-抗糜蛋白酶（ACT）基因中一种常见的信号肽多态性。我们发现AD病例与对照之间ACT多态性的分布没有显著差异，并且未检测到ACT基因型与AD相关的任何影响。因此，我们的数据不支持ACT多态性参与中国汉族人群AD发病风险。《美国医学遗传学杂志》（神经精神遗传学）96:133 - 135，2000年。
