未发现精神分裂症和分裂情感性障碍与13号和8号染色体存在连锁的证据。

Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder.

作者信息

DeLisi L E, Shaw S, Crow T J, Shields G, Smith A B, Larach V W, Wellman N, Loftus J, Nathankumar B, Razi K, Kushner M, Stewart J, Vita A, Comazzi M, Sherrington R

机构信息

Department of Psychiatry, SUNY Stony Brook, Stony Brook, New York 11794, USA.

出版信息

Am J Med Genet. 2000 Apr 3;96(2):235-9. doi: 10.1002/(sici)1096-8628(20000403)96:2<235::aid-ajmg21>3.0.co;2-l.

DOI:10.1002/(sici)1096-8628(20000403)96:2<235::aid-ajmg21>3.0.co;2-l

PMID:10893503

Abstract

A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:235-239, 2000.

摘要

先前一份报告[布洛因等人，1998年：《自然遗传学》20:70 - 73]表明，精神分裂症家族与13号染色体q32区域和8号染色体p21区域存在连锁关系，这促使我们在301个精神分裂症多发家系的大样本中对这些区域进行研究。多点分析未能揭示与13号染色体任何部分存在连锁关系的证据，而使用早期报告中相同的标记，8号染色体p区域仅出现微弱的阳性分数。在一个规模大得多的队列中未能证实布洛因等人的说法，这进一步凸显了精神分裂症连锁关系研究结果的不一致性。《美国医学遗传学杂志》（神经精神遗传学）96:235 - 239，2000年。