Beaulieu C, Busch E, de Crespigny A, Moseley M E
Department of Radiology, Lucas MRI Center, Stanford University, Stanford, California, USA.
Magn Reson Med. 2000 Jul;44(1):110-6. doi: 10.1002/1522-2594(200007)44:1<110::aid-mrm16>3.0.co;2-n.
Diffusion-weighted MRI (DWI), which can detect cortical spreading depressions (SDs) as propagating waves of reduced apparent diffusion coefficient (ADC) of water, was used to investigate whether spreading depression occurs after subarachnoid hemorrhage (SAH) induced by endovascular perforation in the rat. Eleven rats underwent SAH while positioned in the magnet. The ADC measurements had a temporal resolution of 12 sec. Transient decreases in ADC to 74 +/- 5% of pre-SAH values were observed in three rats after SAH, which propagated over the cortex with an average speed of 4.2 +/- 0. 6 mm/min, consistent with an SD wave. Furthermore, in all 11 rats, a wavefront of reduced ADC, which did not resolve within the 12 min observation period, spread at a speed of 3.2 +/- 1.7 mm/min in the ipsilateral cortex, and again is consistent with the speed of SD propagation. Therefore, spreading depression-like cellular depolarization is a consequence of acute subarachnoid hemorrhage in rats. Magn Reson Med 44:110-116, 2000.
扩散加权磁共振成像（DWI）能够将皮质扩散性抑制（SDs）检测为水的表观扩散系数（ADC）降低的传播波，该技术被用于研究大鼠经血管内穿刺诱导蛛网膜下腔出血（SAH）后是否会发生扩散性抑制。11只大鼠在置于磁体中时接受了SAH。ADC测量的时间分辨率为12秒。SAH后在3只大鼠中观察到ADC短暂下降至SAH前值的74±5%，其以平均4.2±0.6毫米/分钟的速度在皮质上传播，与SD波一致。此外，在所有11只大鼠中，ADC降低的波前在同侧皮质以3.2±1.7毫米/分钟的速度传播，在12分钟的观察期内未消散，这同样与SD传播速度一致。因此，扩散性抑制样细胞去极化是大鼠急性蛛网膜下腔出血的一个后果。《磁共振医学》44:110 - 116, 2000。
