Reece W O, Whipp S C, Dougherty R W
Am J Vet Res. 1975 Feb;36(2):223-6.
Four adrenalectomized calves, 3 to 4 months old, were allowed to develop adrenocorticosteroid insufficiency and then were given 50 mg of Escherichia coli endotoxin by infusion via cannula into the duodenum. Several physiologic variables were studied to detect changes indicative of endotoxemia. It is concluded that adrenocorticosteroid insufficiency in calves is not an independent factor allowing an intestinal source of endotoxin to cause the development of clinical signs and physiologic changes characteristic of endotoxemia.
选取了4头3至4月龄的肾上腺切除小牛，使其出现肾上腺皮质类固醇功能不全，然后通过套管经十二指肠输注50毫克大肠杆菌内毒素。研究了几个生理变量以检测表明内毒素血症的变化。得出的结论是，小牛的肾上腺皮质类固醇功能不全并非使肠道来源的内毒素引发内毒素血症特征性临床体征和生理变化的独立因素。
