Sullivan F J, Mroz E A, Miller R E
Ann Surg. 1975 Feb;181(2):232-8. doi: 10.1097/00000658-197502000-00019.
Three hundred dye-dilution curves taken during our first year of clinical experience with the Waters CO-4 cardiac output computer were analyzed to estimate the errors involved in its use. Provided that calibration is accurate and 5.0 mg of dye are injected for each curve, then the percentage standard deviation of measurement using this computer is about 8.7%. Included in this are the errors inherent in the computer, errors due to baseline drift, errors in the injection of dye and acutal variation of cardiac output over a series of successive determinations. The size of this error is comparable to that involved in manual calculation. The mean value of five successive curves will be within 10% of the real value in 99 cases out of 100. Advances in methodology and equipment are discussed which make calibration simpler and more accurate, and which should also improve the quality of computer determination. A list of suggestions is given to minimize the errors involved in the clinical use of this equipment.
对在使用沃特斯CO - 4心输出量计算机的第一年临床经验中获取的300条染料稀释曲线进行了分析，以估算其使用过程中涉及的误差。如果校准准确且每条曲线注入5.0毫克染料，那么使用该计算机测量的百分比标准偏差约为8.7%。这其中包括计算机本身固有的误差、基线漂移引起的误差、染料注射误差以及一系列连续测定中心输出量的实际变化。该误差大小与手工计算所涉及的误差相当。在100个案例中，99个案例里连续五条曲线的平均值将在真实值的10%以内。文中讨论了方法和设备方面的进展，这些进展使校准更简单、更准确，也应能提高计算机测定的质量。还给出了一系列建议，以尽量减少该设备临床使用中涉及的误差。
