[神经元特异性烯醇化酶在儿童神经母细胞瘤预后及随访中的应用。21例回顾性系列研究结果]
[The use of neuron specific enolase in the prognosis and followup of neuroblastoma in children. Results of a retrospective series of 21 patients].
作者信息
Abdennebi M, Boussen H, Harzallah L, Daldoul O, Ghanem A, Gamoudi A, Ben Slimene F, Rahal K, el May A, Ben Ayed F, Guemira F
机构信息
Service de biologie clinique, Institut Salah Azaïz.
出版信息
Tunis Med. 2000 Feb;78(2):106-8.
OBJECTIVE
To report the results of seric neuron specific enolase in pediatric neuroblastoma.
PATIENTS AND METHODS
Our retrospective study concerns 21 children treated in our institution from 1992 to 1998 for neuroblastoma. Seric NSE was determined by immunoenzymology technique at different stages of the disease and the treatment.
RESULTS
Mean value for the 39 dosages of the whole patients was 127.9 ng/ml with a sensitivity of 56%, five patients has presented normal values. Mean value for the 18 patients in stage IV was 132.38 ng/ml. We also observed in 3 patients, an evolution of the seric NSE parallel to this of the disease under chemotherapy.
CONCLUSION
NSE represents a moderate sensitive and specific tumor marker for pediatric neuroblastoma. However, it represents a good value in prognosis and follow-up after chemotherapy.
目的
报告小儿神经母细胞瘤血清神经元特异性烯醇化酶的检测结果。
患者与方法
我们的回顾性研究涉及1992年至1998年在我院接受治疗的21例神经母细胞瘤患儿。采用免疫酶学技术在疾病及治疗的不同阶段测定血清NSE。
结果
全部患者39次检测的平均值为127.9 ng/ml，敏感性为56%，5例患者结果正常。IV期18例患者的平均值为132.38 ng/ml。我们还观察到3例患者在化疗期间血清NSE水平随疾病进展而变化。
结论
NSE是小儿神经母细胞瘤的一种中度敏感且特异的肿瘤标志物。然而，它在化疗后的预后及随访中具有重要价值。
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