Soin J S, Wagner H N, Thomashaw D, Brown T C
Chest. 1975 Mar;67(3):325-30. doi: 10.1378/chest.67.3.325.
Intravascular foreign body thromboembolism and interstitial or vascular granulomata in the lungs are common sequelae to intravenous drug abuse. Early detection of such complications is important, because of the youthful population often involved. Conventional pulmonary function tests, including forced expiratory volumes, diffusion capacity for CO (DLco), chest radiograph and arterial blood gas analysis were performed in 23 narcotic addicts, most of whom had no pulmonary symptoms. The results were compared with radionuclide pulmonary function studies obtained following inhalation of 133Xe gas and injection of 99-mTc albumin microparticles. Thirteen subjects who had normal nonnuclear pulmonary function tests, including DLco and chest radiograph, demonstrated significant abnormalities of regional lung perfusion by lung scan. Of the ten subjects with abnormal DLco all had abnormal perfusion scans and five were noted to have hypoxia at rest. In addition, six of the ten subjects with abnormal DLco revealed a history of concomitant "solid pill abuse" along with heroin abuse, whereas only 2 of 13 subjects with normal DLco admitted tooccasional solid pill abuse. The perfusion lung scan is therefore a sensitive means for detection of early lung disease in narcotic addicts.
血管内异物血栓栓塞以及肺部的间质或血管性肉芽肿是静脉药物滥用常见的后遗症。由于常涉及年轻人群，早期发现此类并发症很重要。对23名吸毒成瘾者进行了常规肺功能测试，包括用力呼气量、一氧化碳弥散量（DLco）、胸部X光片和动脉血气分析，其中大多数人没有肺部症状。将结果与吸入133Xe气体和注射99mTc白蛋白微粒后获得的放射性核素肺功能研究结果进行比较。13名非核肺功能测试正常（包括DLco和胸部X光片）的受试者经肺部扫描显示区域肺灌注有明显异常。在10名DLco异常的受试者中，所有人的灌注扫描均异常，其中5人被发现静息时存在低氧血症。此外，10名DLco异常的受试者中有6人有同时滥用“固体药丸”和海洛因的病史，而13名DLco正常的受试者中只有2人承认偶尔滥用固体药丸。因此，灌注肺扫描是检测吸毒成瘾者早期肺部疾病的一种敏感方法。
