Briton-Jones C, Haines C J
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Hong Kong Med J. 2000 Jun;6(2):184-9.
Significant advances in treatment have enabled previously infertile males to achieve fatherhood, when only a few years ago they would have had no chance of biological paternity. In contrast to the overall success of assisted reproduction, the aetiology of male-factor infertility is poorly understood. Recent studies have shown, however, that a significant proportion of men with severe infertility have microdeletions of the Y chromosome. Furthermore, reports have shown that male infants conceived through assisted reproductive techniques have inherited the same Y-chromosome microdeletion as their fathers. It has thus become important to screen men who are at risk of Y-chromosome microdeletions, as this will determine if counselling is needed prior to starting infertility treatment. This review examines the significance and limitations of the current understanding of Y-chromosome microdeletions in male infertility.
治疗方面的重大进展使以前不育的男性能够成为父亲，而就在几年前，他们还没有生物学意义上的亲子关系的机会。与辅助生殖的总体成功形成对比的是，人们对男性因素不育的病因了解甚少。然而，最近的研究表明，相当一部分严重不育的男性存在Y染色体微缺失。此外，有报告显示，通过辅助生殖技术受孕的男婴继承了与他们父亲相同的Y染色体微缺失。因此，对有Y染色体微缺失风险的男性进行筛查变得很重要，因为这将决定在开始不育治疗之前是否需要咨询。这篇综述探讨了目前对男性不育中Y染色体微缺失的理解的意义和局限性。
