Surbek D V, Tercanli S, Holzgreve W
Department of Obstetrics and Gynecology, University of Basel, Switzerland.
Ultrasound Obstet Gynecol. 2000 Apr;15(4):302-7. doi: 10.1046/j.1469-0705.2000.00089.x.
To explore the potential of embryofetoscopy for early diagnosis and for access to the fetal circulation in the first trimester of gestation.
Transabdominal embryofetoscopy was performed in 14 patients scheduled for termination of pregnancy using a 1-mm semirigid fibreoptic telescope with a 18 gauge examination sheath and a single-chip digital camera. A 25 gauge needle was inserted through an additional 21 gauge side port to access the fetal circulation.
Fetal head, face, abdomen, complete upper and lower limbs could be visualized in over 80% of cases. On the contrary, the fetal back and external genitalia could be examined in detail only in some cases (35.7% and 64.3%, respectively). Injection of 10-20 ml saline improved visibility in 43% of cases. Funipuncture was successful in two of three attempts.
Our experience suggests that embryofetoscopy is a useful tool for early diagnosis in the first trimester of pregnancy. Funipuncture is possible thus providing the means for an early intravascular stem cell application.
探讨胚胎胎儿镜在妊娠早期进行早期诊断及进入胎儿循环的潜力。
对14例计划终止妊娠的患者进行经腹胚胎胎儿镜检查，使用带有18号检查鞘的1毫米半刚性光纤望远镜和单芯片数码相机。通过额外的21号侧孔插入一根25号针以进入胎儿循环。
超过80%的病例中可观察到胎儿头部、面部、腹部、完整的上肢和下肢。相反，仅在部分病例中能详细检查胎儿背部和外生殖器（分别为35.7%和64.3%）。43%的病例中注入10 - 20毫升生理盐水可提高视野清晰度。三次尝试中有两次成功进行了脐血管穿刺。
我们的经验表明，胚胎胎儿镜是妊娠早期进行早期诊断的有用工具。脐血管穿刺是可行的，从而为早期血管内干细胞应用提供了途径。
