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The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group.

作者信息

Gardner T W, Antonetti D A, Barber A J, Lieth E, Tarbell J A

机构信息

Department of Ophthalmology, Penn State University College of Medicine, Hershey 17033, USA.

出版信息

Doc Ophthalmol. 1999;97(3-4):229-37. doi: 10.1023/a:1002140812979.

DOI:10.1023/a:1002140812979
PMID:10896336
Abstract
摘要

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Exp Eye Res. 2010 Sep;91(3):387-92. doi: 10.1016/j.exer.2010.06.010. Epub 2010 Jun 19.
5
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Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors.
J Biol Chem. 1999 Aug 13;274(33):23463-7. doi: 10.1074/jbc.274.33.23463.
2
Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.实验性糖尿病中的血管通透性与内皮紧密连接蛋白含量降低有关:血管内皮生长因子可降低视网膜内皮细胞中的紧密连接蛋白。宾夕法尼亚州立大学视网膜研究小组。
Diabetes. 1998 Dec;47(12):1953-9. doi: 10.2337/diabetes.47.12.1953.
3
Expression of zonula occludens and adherens junctional proteins in human venous and arterial endothelial cells: role of occludin in endothelial solute barriers.紧密连接和黏附连接蛋白在人静脉和动脉内皮细胞中的表达:闭合蛋白在内皮溶质屏障中的作用
HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies.HK2 介导的小鼠光感受器糖酵解代谢对于晚期年龄相关性黄斑变性样病变的发生并非必需。
Biomolecules. 2021 Jun 11;11(6):871. doi: 10.3390/biom11060871.
4
Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis.低剂量重组腺相关病毒介导的血管内皮生长因子抑制可治疗新生血管病变而不引起视网膜血管炎。
Hum Gene Ther. 2021 Jul;32(13-14):649-666. doi: 10.1089/hum.2021.132.
5
Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1.创伤性脑损伤后中枢神经系统屏障的炎症调节:白介素-1 导演的故事。
Front Immunol. 2021 May 21;12:688254. doi: 10.3389/fimmu.2021.688254. eCollection 2021.
6
Lipidomics of the brain, retina, and biofluids: from the biological landscape to potential clinical application in schizophrenia.脑、视网膜和生物体液的脂质组学:从生物学领域到精神分裂症的潜在临床应用。
Transl Psychiatry. 2020 Nov 9;10(1):391. doi: 10.1038/s41398-020-01080-1.
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The Benefits of Flavonoids in Diabetic Retinopathy.类黄酮在糖尿病视网膜病变中的益处。
Nutrients. 2020 Oct 16;12(10):3169. doi: 10.3390/nu12103169.
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Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress.卵磷脂结合碘可防止缺氧应激下视网膜色素上皮细胞紧密连接的破坏。
J Ophthalmol. 2016;2016:9292346. doi: 10.1155/2016/9292346. Epub 2016 May 31.
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Vascular permeability--the essentials.血管通透性——要点
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Vascular endothelial growth factor levels in tears of patients with retinal vein occlusion.视网膜静脉阻塞患者泪液中血管内皮生长因子水平
Graefes Arch Clin Exp Ophthalmol. 2015 Sep;253(9):1581-6. doi: 10.1007/s00417-015-3030-2. Epub 2015 May 9.
Microcirculation. 1998;5(2-3):197-210.
4
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.ZO-3是一种在紧密连接处发现的MAGUK蛋白家族的新成员,它与ZO-1和闭合蛋白相互作用。
J Cell Biol. 1998 Apr 6;141(1):199-208. doi: 10.1083/jcb.141.1.199.
5
Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells.星形胶质细胞增强视网膜血管内皮细胞的屏障特性和紧密连接蛋白1(ZO-1)的表达。
Invest Ophthalmol Vis Sci. 1997 Oct;38(11):2423-7.
6
Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: comparison with vascular endothelial growth factor, tumor necrosis factor alpha, and interleukin-1beta-mediated breakdown.实验性自身免疫性葡萄膜视网膜炎中的血视网膜屏障(BRB)破坏:与血管内皮生长因子、肿瘤坏死因子α及白细胞介素-1β介导的破坏的比较
J Neurosci Res. 1997 Aug 1;49(3):268-80. doi: 10.1002/(sici)1097-4547(19970801)49:3<268::aid-jnr2>3.0.co;2-a.
7
Physiological transport properties of cultured retinal microvascular endothelial cell monolayers.
Curr Eye Res. 1997 Aug;16(8):761-8. doi: 10.1076/ceyr.16.8.761.8991.
8
Occludin as a possible determinant of tight junction permeability in endothelial cells.闭合蛋白作为内皮细胞紧密连接通透性的一个可能决定因素。
J Cell Sci. 1997 Jul;110 ( Pt 14):1603-13. doi: 10.1242/jcs.110.14.1603.
9
Possible involvement of phosphorylation of occludin in tight junction formation.紧密连接形成过程中紧密连接蛋白磷酸化的可能作用。
J Cell Biol. 1997 Jun 16;137(6):1393-401. doi: 10.1083/jcb.137.6.1393.
10
Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells.组胺可降低培养的视网膜微血管内皮细胞中闭锁小带蛋白1(ZO-1)的表达。
Biochem J. 1996 Dec 15;320 ( Pt 3)(Pt 3):717-21. doi: 10.1042/bj3200717.