Bienzle D, Silverstein D C, Chaffin K
Department of Pathobiology, University of Guelph, ON, Canada.
Vet Pathol. 2000 Jul;37(4):364-9. doi: 10.1354/vp.37-4-364.
Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficiency involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.
在两只患有单克隆球蛋白血症、蛋白尿和骨髓浆细胞增殖的猫中诊断出多发性骨髓瘤。一只猫的脊椎骨髓发生了产生免疫球蛋白G的骨髓瘤，对手术减压后联合局部放疗和化疗有两次反应。这只猫的存活时间约为2年。另一只出现高钙血症和肾功能不全的猫的骨髓瘤累及内脏器官，血清电泳显示由于免疫球蛋白A二聚体形成出现双克隆峰。这只猫的肿瘤对化疗无反应。
