Arnold S, Berthele A, Drzezga A, Tölle T R, Weis S, Werhahn K J, Henkel A, Yousry T A, Winkler P A, Bartenstein P, Noachtar S
Department of Neurology, University of Munich, Germany.
Epilepsia. 2000 Jul;41(7):818-24. doi: 10.1111/j.1528-1157.2000.tb00248.x.
Comparison of regional reduction of GABA receptor binding and seizure onset zone in patients with extratemporal epilepsy due to focal cortical dysplasia.
Two patients with frontal lobe epilepsy who remained seizure free after partial frontal lobe resection were investigated with magnetic resonance imaging, positron emission tomography (PET) with 18F-fluoro-deoxy-glucose (FDG) and 11C-flumazenil, subdural EEG-video recordings, and postoperative benzodiazepine (BDZ)-receptor autoradiography.
The area of reduced BDZ-receptor binding as documented by preoperative flumazenil-PET and postoperative BDZ-receptor autoradiography corresponded to the seizure onset zone and was smaller than the interictal hypometabolism documented by FDG-PET.
Flumazenil-PET is a useful tool for localization of the epileptogenic zone in patients with extratemporal epilepsy caused by focal cortical dysplasia. Neuronal distribution of BDZ-receptor density confirms in vivo flumazenil-PET findings. The regional reduction of BDZ-receptor binding in focal cortical dysplasia seems to be confined to the seizure onset zone and not to the extent of dysplastic cortex.
比较局灶性皮质发育不良所致颞叶外癫痫患者γ-氨基丁酸（GABA）受体结合区域减少情况与癫痫发作起始区。
对2例部分额叶切除术后无癫痫发作的额叶癫痫患者进行磁共振成像、18F-氟脱氧葡萄糖（FDG）和11C-氟马西尼正电子发射断层扫描（PET）、硬膜下脑电图-视频记录以及术后苯二氮䓬（BDZ）受体放射自显影检查。
术前氟马西尼-PET和术后BDZ受体放射自显影记录的BDZ受体结合减少区域与癫痫发作起始区相对应，且小于FDG-PET记录的发作间期低代谢区域。
氟马西尼-PET是定位局灶性皮质发育不良所致颞叶外癫痫患者致痫区的有用工具。BDZ受体密度的神经元分布证实了体内氟马西尼-PET的结果。局灶性皮质发育不良中BDZ受体结合的区域减少似乎局限于癫痫发作起始区，而非发育异常皮质的范围。
