Katakami N, Takakura S, Fujii H, Nishimura T, Umeda B
Dept. of Pulmonary Disease, Kobe City General Hospital.
Gan To Kagaku Ryoho. 2000 Jun;27(6):865-71.
Chemotherapy plus granulocyte colony-stimulating factor (G-CSF) induced mobilization of peripheral blood stem cells (PBSC) was performed in patients with limited stage small-cell lung cancer. Chemotherapy consisted of cisplatin/etoposide or cisplatin/adriamycin/etoposide. The amounts of CD34 positive cells and granulocyte-macrophage colony forming units (CFU-GM) collected during 2-3 courses of apheresis were 3.1 +/- 2.9 x 10(6)/kg (n = 10) and 3.1 +/- 1.5 x 10(5)/kg (n = 8), respectively. Adequate amounts of PBSC were also harvested even in patients treated with concurrent chemoradiotherapy. Eight patients were successfully treated with high-dose chemotherapy consisting of ifosfamide, carboplatin and etoposide with PBSC transfusion. The patients'-bone marrow reconstruction was rapid and no treatment-related death was observed.
对局限期小细胞肺癌患者进行了化疗联合粒细胞集落刺激因子（G-CSF）诱导的外周血干细胞（PBSC）动员。化疗方案为顺铂/依托泊苷或顺铂/阿霉素/依托泊苷。在2 - 3个疗程的单采过程中收集的CD34阳性细胞数量和粒-巨噬细胞集落形成单位（CFU-GM）分别为3.1±2.9×10⁶/kg（n = 10）和3.1±1.5×10⁵/kg（n = 8）。即使是接受同步放化疗的患者也采集到了足够数量的PBSC。8例患者接受了由异环磷酰胺、卡铂和依托泊苷组成的大剂量化疗并进行了PBSC输注，治疗成功。患者的骨髓重建迅速，未观察到与治疗相关的死亡。
