Paklina O V, Galil-Ogly G A, Bershchanskaia A M, Alipchenko L A
Russian Roentgenoradiological Research Centre, Moscow.
Arkh Patol. 2000 May-Jun;62(3):21-4.
Clinicomorphological analysis was performed in 12 cases of atypical adenomatous hyperplasia of the lung (AAH). This is the proliferative lesion consisting of atypical epithelial cells along the alveolar septa which are found incidentally during pathologic examination of the lung resected because of cancer. We studied morphological and biological characteristics of AAH cells including cytodifferentiation, proliferative activity, tumor-suppressor genes. Our review of the studies of AAH revealed that AAH is alveolar intraepithelial dysplasia and a precursor of lung adenocarcinoma. AAH is an important lesion corresponding to a step in carcinogenesis for peripheral lung adenocarcinomas.
对12例肺非典型腺瘤样增生（AAH）进行了临床形态学分析。这是一种增殖性病变，由沿肺泡间隔的非典型上皮细胞组成，在因癌症切除的肺组织病理检查中偶然发现。我们研究了AAH细胞的形态学和生物学特性，包括细胞分化、增殖活性、肿瘤抑制基因。我们对AAH研究的综述表明，AAH是肺泡上皮内发育异常，是肺腺癌的前体。AAH是外周型肺腺癌致癌过程中一个重要的对应阶段的病变。
