Sakata K
Department of Otolaryngology, Yamagata University, School of Medicine.
Nihon Jibiinkoka Gakkai Kaiho. 2000 Jun;103(6):734-41. doi: 10.3950/jibiinkoka.103.734.
We examined urea used as a dilution marker of broncho-alveolar lavage fluid to determine whether it was also useful as a dilution marker of nasal lavage fluid. We measured the concentration of urea in nasal secretions and peripheral blood for 91 cases. As a comparison, we also measured the total protein and albumin in nasal secretions and peripheral blood. The urea concentrations in nasal secretions were strongly correlated with that in peripheral blood (coefficient of correlation 0.925). The urea concentration in nasal secretions was approximately 2.4 times higher than the level in peripheral blood. No correlation was observed between total protein or albumin levels in nasal secretions and those in peripheral blood. In two patients with Japanese cedar pollinosis, we measured histamine concentration in nasal lavage fluid. Although no change in histamine concentration was observed by direct measurement, after the values were corrected for urea level, an increase in histamine was clearly observed during the cedar pollen season. The urea method was found to be useful as a dilution marker for nasal lavage fluid.
我们检测了用作支气管肺泡灌洗液稀释标志物的尿素，以确定其是否也可用作鼻腔灌洗液的稀释标志物。我们测量了91例患者鼻腔分泌物和外周血中尿素的浓度。作为对照，我们还测量了鼻腔分泌物和外周血中的总蛋白及白蛋白。鼻腔分泌物中的尿素浓度与外周血中的尿素浓度高度相关（相关系数0.925）。鼻腔分泌物中的尿素浓度约为外周血中尿素浓度的2.4倍。鼻腔分泌物中的总蛋白或白蛋白水平与外周血中的总蛋白或白蛋白水平之间未观察到相关性。在两名日本雪松花粉症患者中，我们测量了鼻腔灌洗液中的组胺浓度。虽然直接测量未观察到组胺浓度的变化，但在校正尿素水平后，在雪松花粉季节期间明显观察到组胺增加。发现尿素法可用作鼻腔灌洗液的稀释标志物。
