Kamińska A, Jung A, Piechota W, Kałuza D
Kliniki Pediatrii i Nefrologii Dzieciecej CSK WAM w Warszawie.
Pol Merkur Lekarski. 2000 Apr;8(46):181-2.
Inhibitors of crystallization process play an important role in renal-stone forming patients. One of well-known inhibitor is citrate. The aim of the study was to define the type of metabolic abnormality in children with nephrolithiasis and the role of urinary citrate excretion. 52 children with nephrolithiasis were examined. Hypocitraturia was observed in 42.3% of patients, most frequently in children with hypercalciuria, hyperoxaluria, and hyperoxaluria with hyperuricosuria. Low urinary citrate excretion found in patients with nephrolithiasis may play an important role in the pathogenesis of the disease. Urinary citrate excretion should be examined in patients with nephrolithiasis.
结晶过程抑制剂在肾结石形成患者中起着重要作用。一种著名的抑制剂是柠檬酸盐。该研究的目的是确定肾结石患儿的代谢异常类型以及尿柠檬酸盐排泄的作用。对52例肾结石患儿进行了检查。42.3%的患者出现低枸橼酸尿，最常见于高钙尿症、高草酸尿症以及高草酸尿症合并高尿酸尿症的患儿。肾结石患者中发现的低尿柠檬酸盐排泄可能在该疾病的发病机制中起重要作用。肾结石患者应检查尿柠檬酸盐排泄情况。
