[膀胱输尿管反流和复发性尿路感染患儿的β2微球蛋白尿症]
[Beta-2 microglobulinuria in children with vesico-ureteral reflux and recurrent urinary tract infections].
作者信息
Kamińska A, Jung A, Olszewski S, Muszyńska J, Dadas E
机构信息
Kliniki Pediatrii i Nefrologii Dzieciecej CSK WAM w Warszawie.
出版信息
Pol Merkur Lekarski. 2000 Apr;8(46):240-1.
Recurrent urinary tract infections in children with vesico-ureteral reflux are the one of risk factors in the process of reflux nephropathy. One of markers of early kidney parenchyma damage is beta 2-microglobulin. The aim of the study was to evaluate the value of beta 2-microglobulin excretion in urine and its serum levels in children with vesico-ureteral reflux and recurrent urinary tract infections. It was found that abnormal urinary excretion of beta 2-microglobulin and its serum levels of proceeded post-inflammatory changes in kidney parenchyma observed in imaging examinations of urinary tract and impared parameters of renal function in biochemical analyses.
膀胱输尿管反流患儿反复发生尿路感染是反流性肾病发病过程中的危险因素之一。早期肾实质损害的标志物之一是β2微球蛋白。本研究的目的是评估膀胱输尿管反流和反复尿路感染患儿尿中β2微球蛋白排泄量及其血清水平的价值。研究发现，β2微球蛋白尿排泄异常及其血清水平与尿路影像学检查中观察到的肾实质炎症后改变以及生化分析中肾功能参数受损有关。
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