Herrerías Gutiérrez J M
An R Acad Nac Med (Madr). 1999;116(4):793-811; discussion 811-3.
The relationship between Helicobacter pylori (H. pylori) infection and gastroesophageal reflux disease (GERD) is not well known yet, and has some controversial issues. There is indirect epidemiological evident, not yet proven, that H. pylori may have a protective role against GERD. Hypochlorhydria caused by gastritis located mainly at corpus would be the principal physiopathological protector mechanism against GERD. Even knowing that more studies are needed, the risk of developing GERD after the H. pylori eradication seems to be increased in some groups of patients. In the presence of the microorganism, the efficacy of acid suppression therapy may decrease, and its long-term use could favour the progression to corpus atrophic gastritis. Specialized intestinal metaplasia in an endoscopically normal-appearing cardia may precede adenocarcinoma, and its prevention would vary, depending on its controversial origin, secondary to carditis, H. pylori or GERD.
幽门螺杆菌（H. pylori）感染与胃食管反流病（GERD）之间的关系尚不明确，且存在一些争议性问题。有尚未得到证实的间接流行病学证据表明，幽门螺杆菌可能对胃食管反流病具有保护作用。主要位于胃体部的胃炎导致的胃酸过少可能是预防胃食管反流病的主要生理病理保护机制。即便知道还需要更多研究，但在某些患者群体中，根除幽门螺杆菌后发生胃食管反流病的风险似乎有所增加。在存在该微生物的情况下，抑酸治疗的疗效可能会降低，长期使用抑酸治疗可能会促使病情发展为胃体萎缩性胃炎。在内镜检查外观正常的贲门处出现的特殊肠化生可能先于腺癌出现，其预防方法会因有争议的起源（继发于贲门炎、幽门螺杆菌或胃食管反流病）而有所不同。
