刀豆氨酸介导的大肠杆菌多胺池消耗：头部形态发生和DNA合成的影响。
Canavanine-mediated depletion of polyamine pools in Escherichia coli: effect of head morphogenesis and DNA synthesis.
作者信息
Bolin R W, Cummings D J
出版信息
J Virol. 1975 Feb;15(2):232-7. doi: 10.1128/JVI.15.2.232-237.1975.
Abstract
We have found that L-canavanine inhibited the synthesis of polyamines in T4-infected Escherichia coli. These polyamines are known to be required for T4 DNA synthesis and may be involved in phage morphogenesis. The new data indicate that the inhibition of polyamine synthesis is not primarily responsible for the L-conavanine-mediated inhibition of DNA synthesis nor does it seem to be involved in the induction of lollipops. L-Canavanine does influence the relative amounts of putrescine and spermidine found in the phage particle, but it does not influence the amount of DNA phosphate neutralized by polyamines.
摘要
我们发现L-刀豆氨酸可抑制T4噬菌体感染的大肠杆菌中多胺的合成。已知这些多胺是T4噬菌体DNA合成所必需的，并且可能参与噬菌体形态发生。新数据表明，多胺合成的抑制并非L-刀豆氨酸介导的DNA合成抑制的主要原因，也似乎不参与棒棒糖结构的诱导。L-刀豆氨酸确实会影响噬菌体颗粒中腐胺和亚精胺的相对含量，但不会影响被多胺中和的DNA磷酸盐的量。
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引用本文的文献
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Bacteriol Rev. 1976 Jun;40(2):314-59. doi: 10.1128/br.40.2.314-359.1976.
本文引用的文献
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Genetic and chemical studies on the head protein of bacteriophages T2 and T4.噬菌体T2和T4头部蛋白的遗传学与化学研究
Brookhaven Symp Biol. 1959 Nov;12:86-94.
2
The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.多胺在噬菌体脱氧核糖核酸中和中的作用。
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Bacteriophage T4 head morphogenesis. On the nature of gene 49-defective heads and their role as intermediates.噬菌体T4头部形态发生。关于基因49缺陷型头部的性质及其作为中间体的作用。
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Multiple pathways of putrescine biosynthesis in Escherichia coli.大肠杆菌中腐胺生物合成的多种途径。
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A biosynthetic ornithine decarboxylase in Escherichia coli.大肠杆菌中的一种生物合成鸟氨酸脱羧酶。
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Putrescine biosynthesis in Escherichia coli. Regulation through pathway selection.大肠杆菌中腐胺的生物合成。通过途径选择进行调控。
J Biol Chem. 1969 Nov 25;244(22):6094-9.
7
Structural aberrations in T-even bacteriophage. V. Effects of canavanine on the maturation and utilization of specific gene products.T-偶数噬菌体中的结构畸变。V. 刀豆氨酸对特定基因产物成熟和利用的影响。
J Virol. 1974 Jun;13(6):1378-91. doi: 10.1128/JVI.13.6.1378-1391.1974.
8
Structural aberrations in T-even bacteriophage. IV. Parameters of induction and formation of lollipops.T-偶数噬菌体的结构畸变。IV. 棒棒糖结构的诱导和形成参数。
J Virol. 1974 Jun;13(6):1368-77. doi: 10.1128/JVI.13.6.1368-1377.1974.
9
Intracellular events in canavanine-treated, T4-infected Escherichia coli.
Virology. 1972 Dec;50(3):765-71. doi: 10.1016/0042-6822(72)90430-8.
10
Infection of Escherichia coli by T2 and T4 bacteriophages as seen in the electron microscope: T4 head morphogenesis.在电子显微镜下观察到的T2和T4噬菌体对大肠杆菌的感染：T4头部形态发生。
Proc Natl Acad Sci U S A. 1972 Apr;69(4):907-11. doi: 10.1073/pnas.69.4.907.
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