Willis A, Hyland P, Lamey P J
Department of Oral Surgery, Oral Medicine & Oral Pathology, School of Clinical Dentistry, The Queen's University of Belfast, Northern Ireland.
Eur J Clin Microbiol Infect Dis. 2000 May;19(5):355-7. doi: 10.1007/s100960050493.
This study investigated the effects of iron replacement on the incidence of recurrent herpes labialis and serum ferritin levels in patients with sideropenia. Ten patients with diagnosed sideropenia and a history of recrudescent herpes labialis were prescribed ferrous sulphate for a period of 3 months. Patients were questioned on the number of episodes of recrudescent herpes labialis that developed per month before treatment and the number of episodes of recrudescent herpes labialis that developed per month after the commencement of replacement iron therapy and during the follow-up period. All blood samples were collected by venipuncture for assay of ferritin levels. Serum ferritin levels were significantly increased compared to pretreatment levels (P<0.05). The number of monthly episodes of recrudescent herpes labialis was reduced from 0.78 to 0.2 episodes per month following treatment (P<0.05). The findings of this study suggest that iron replacement therapy should be further studied as a treatment option in sideropenic individuals with frequent recurrences of recrudescent herpes labialis.
本研究调查了铁剂补充对缺铁性贫血患者复发性唇疱疹发病率及血清铁蛋白水平的影响。10例已确诊缺铁性贫血且有复发性唇疱疹病史的患者，服用硫酸亚铁3个月。询问患者治疗前每月复发性唇疱疹发作次数，以及补充铁剂治疗开始后及随访期间每月复发性唇疱疹发作次数。所有血样均通过静脉穿刺采集，用于检测铁蛋白水平。与治疗前水平相比，血清铁蛋白水平显著升高（P<0.05）。治疗后，复发性唇疱疹每月发作次数从0.78次降至0.2次（P<0.05）。本研究结果表明，对于复发性唇疱疹频繁发作的缺铁性贫血患者，铁剂补充疗法作为一种治疗选择应进一步研究。
