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后肢卸载14天后大鼠比目鱼肌运动单位中肌纤维组成的表型变化。

Phenotypic changes in the composition of muscular fibres in rat soleus motor units after 14 days of hindlimb unloading.

作者信息

Picquet F, Canu M H, Falempin M

机构信息

Université des Sciences et Technologies de Lille, Laboratoire de Plasticité Neuromusculaire, Villeneuve D'Ascq, France.

出版信息

Pflugers Arch. 2000 Jun;440(2):229-35. doi: 10.1007/s004240000288.

DOI:10.1007/s004240000288
PMID:10898523
Abstract

The main goal of this study was to identify the different fibre types of the motor units (MUs) contained in the soleus muscles from control (CONT) rats and from rats submitted to 14 days of hindlimb unloading (HU). The MU types were classified according to their contractile properties and also using glycogen depletion followed by adenosine triphosphatase (ATPase) staining. In CONT rats, the soleus muscle contained two MU types identified as slow and fast types. After HU, the MU distribution showed three populations: slow, intermediate and fast. All the MUs from HU soleus were heterogeneous in terms of fibre type composition, indicating a complex remodelling of the muscle.

摘要

本研究的主要目的是确定对照组(CONT)大鼠和经历14天 hindlimb unloading(HU)的大鼠比目鱼肌中运动单位(MU)的不同纤维类型。MU类型根据其收缩特性进行分类,并且还通过糖原耗竭后进行三磷酸腺苷酶(ATPase)染色来分类。在CONT大鼠中,比目鱼肌包含两种被鉴定为慢肌纤维型和快肌纤维型的MU类型。HU后,MU分布显示出三个群体:慢肌纤维型、中间型和快肌纤维型。HU比目鱼肌的所有MU在纤维类型组成方面都是异质的,表明肌肉发生了复杂的重塑。

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