Yang T S, Hsu K C, Tang R, Chang T C
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Anticancer Drugs. 2000 Apr;11(4):279-83. doi: 10.1097/00001813-200004000-00009.
Ovarian metastasis may present at the time of initial diagnosis of colon carcinoma or as a later recurrence. Little meaningful information is available regarding the treatment and outcome of synchronous ovarian metastasis of colon carcinoma. This report describes the clinical course of five patients with synchronous ovarian metastasis of colon carcinoma who were treated with aggressive surgery and chemotherapy. The treatment consisted of maximal surgical debulking followed by systemic chemotherapy with weekly 24 h infusion of high-dose 5-fluorouracil and leucovorin. All of the five patients had subsequent disease-free periods ranging from 6 to 43+ months following operation. Two of the patients who had no or minimal peritoneal involvement were still alive without disease at 33 and 43 months. The data from these cases suggest that aggressive surgery and systemic chemotherapy may be highly efficacious in the treatment of colon carcinoma with synchronous ovarian metastasis. Maximal debulking followed by chemotherapy may be particularly effective in those patients with minimal peritoneal involvement.
卵巢转移可能在结肠癌初诊时出现，或作为晚期复发出现。关于结肠癌同时性卵巢转移的治疗及预后，几乎没有有意义的信息。本报告描述了5例结肠癌同时性卵巢转移患者接受积极手术和化疗的临床过程。治疗包括最大程度的手术减瘤，随后进行全身化疗，每周24小时输注高剂量5-氟尿嘧啶和亚叶酸钙。所有5例患者术后均有6至43个多月的无病期。2例无或仅有轻微腹膜受累的患者在33个月和43个月时仍无病存活。这些病例的数据表明，积极的手术和全身化疗在治疗结肠癌同时性卵巢转移方面可能非常有效。最大程度减瘤后进行化疗对那些腹膜受累轻微的患者可能特别有效。
