Altfeld M, Rosenberg E S
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA.
Curr Opin Immunol. 2000 Aug;12(4):375-80. doi: 10.1016/s0952-7915(00)00103-5.
Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-1-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and CTL responses in HIV-1 infection.
病毒特异性CD4(+) T细胞辅助和CD8(+) 细胞毒性T细胞（CTL）反应对于维持慢性病毒感染中的有效免疫至关重要。HIV-1感染呈现出一种独特的情况，即HIV-1特异性T辅助细胞反应典型地受损，并且随着疾病进展，病毒特异性CTL会随时间逐渐减少；在HIV-1感染中，T细胞辅助和CTL反应之间存在一种关系。
