Kreis M E, Müller M, Zittel T T, Glatzle J, Grundy D
University Hospital Tübingen, Department of General Surgery, Tübingen, Germany.
Neurosci Lett. 2000 Jul 28;289(1):45-8. doi: 10.1016/s0304-3940(00)01265-9.
Brainstem neurones become activated following intestinal antigen challenge but the signalling mechanisms have not been resolved. Our aim was to determine the extent of brainstem activation after intestinal anaphylaxis induced by chicken egg albumin (EA). An increase in Fos-positive neurones in the nucleus tractus solitarius (nTS) was observed following EA (P<0.05). Fos-expression was decreased following pretreatment with pyrilamine and ondansetron i.p. and to a similar extent when both antagonists were administered together (all P<0.05 vs. control). Indomethacin had no effect on Fos-expression after antigen challenge. 5-HT and histamine but not prostanoids, released following intestinal anaphylaxis, induce nTS activation via histamine H(1)- and 5-HT(3) receptors. Information on the intestinal inflammatory status is relayed centrally and may play a role in reflexes and behavioural responses to activation of the immune system.
肠道抗原刺激后脑干神经元被激活，但信号传导机制尚未明确。我们的目的是确定卵清蛋白（EA）诱导肠道过敏反应后脑干激活的程度。EA刺激后孤束核（nTS）中Fos阳性神经元增加（P<0.05）。腹腔注射苯吡胺和昂丹司琼预处理后Fos表达降低，两种拮抗剂联合使用时降低程度相似（与对照组相比均为P<0.05）。吲哚美辛对抗原刺激后的Fos表达无影响。肠道过敏反应后释放的5-羟色胺和组胺而非前列腺素，通过组胺H(1)和5-羟色胺3型受体诱导nTS激活。关于肠道炎症状态的信息被中枢传递，可能在对免疫系统激活的反射和行为反应中起作用。
