正常男性对促黄体生成激素释放激素的反应。
The response to luteinizing hormone-releasing hormone in normal men.
作者信息
Shahmanesh M, Boyns A R, Ellwood M, Groom G V, Nelson E, Hartog M
出版信息
Postgrad Med J. 1975 Feb;51(592):59-64. doi: 10.1136/pgmj.51.592.59.
Synthetic luteinizing hormone-releasing hormone (LH-RH) was given in doses of 11-100 μg to normal men. Doses of 50 and 100 μg caused a two- to ten-fold rise in serum LH in all subjects, but in only 40% was the serum follicle-stimulating hormone (FSH) elevated. A significantly higher LH response to LH-RH was seen in subjects in whom a rise in serum FSH could be detected. Although there was a wide variation in the serum gonadotrophic hormone response, the test was reproducible in individual subjects. A significant rise of serum LH was seen following the injection of 1 μg LH-RH and a linear log-dose response occurred over the range 0·25 to 4 μg. There was no rise in serum FSH with the lower doses of LH-RH. Two injections of LH-RH 90 min apart produced comparable rises of serum LH and FSH. The rise of serum LH following a second injection of LH-RH was blunted when the two injections were given 30 or 45 min apart.
向正常男性注射剂量为11 - 100微克的合成促黄体生成素释放激素（LH - RH）。50微克和100微克的剂量可使所有受试者血清促黄体生成素（LH）升高2至10倍，但只有40%的受试者血清促卵泡生成素（FSH）升高。在能检测到血清FSH升高的受试者中，观察到对LH - RH的LH反应明显更高。尽管血清促性腺激素反应存在很大差异，但该测试在个体受试者中具有可重复性。注射1微克LH - RH后血清LH显著升高，在0·25至4微克范围内出现线性对数剂量反应。较低剂量的LH - RH不会使血清FSH升高。间隔90分钟注射两次LH - RH可使血清LH和FSH产生相当的升高。当两次注射间隔30或45分钟时，第二次注射LH - RH后血清LH的升高会减弱。
Zotero 插件