Craig G M
Postgrad Med J. 1975 Feb;51(592):74-84. doi: 10.1136/pgmj.51.592.74.
The role of prostaglandins in reproductive physiology is reviewed with particular emphasis on their possible importance in ovulation in humans. A possible interaction between gonadal steroids, biogenic amines and prostaglandins at hypothalamic-pituitary level, in relation to the release of luteinizing hormone releasing factor, and LH, is discussed. Anomalies regarding the role of oestrogens in LH release are noted, and it is suggested that high oestrogen levels may release prostaglandins from the uterus and/or centrally in humans, in connection with the mid-cycle LH surge and ovulation. A hypothetical role for prostaglandins in sexual behaviour and premenstrual changes is discussed. The hypotheses open up new areas for clinical research to establish the role of prostaglandins in human endocrinology. The need for measurement of prostaglandin metabolites in blood and urine is emphasized.
本文综述了前列腺素在生殖生理学中的作用，特别强调了它们在人类排卵中可能具有的重要性。讨论了性腺类固醇、生物胺和前列腺素在下丘脑-垂体水平上，与促黄体生成素释放因子及促黄体生成素释放之间可能存在的相互作用。文中指出了雌激素在促黄体生成素释放作用方面的异常情况，并提出高雌激素水平可能与人类月经周期中期促黄体生成素激增及排卵有关，从而促使子宫和/或中枢释放前列腺素。文中还讨论了前列腺素在性行为和经前变化中的假设作用。这些假设为临床研究开辟了新领域，以确定前列腺素在人类内分泌学中的作用。文中强调了测量血液和尿液中前列腺素代谢物的必要性。
