Tsurita G, Nagawa H, Ueno S, Watanabe S, Taki M
Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
Bioelectromagnetics. 2000 Jul;21(5):364-71.
We investigated the effects of exposure to a 1439 MHz TDMA (Time Division Multiple Access) field, as used in cellular phones, on the permeability of the blood-brain barrier (BBB), on the morphological changes of the brain, and on body-mass fluctuations. Male Sprague-Dawley (SD) rats were divided into three groups of eight rats each. The rats in the EM(+) group, which had their heads arrayed in a circle near the central antenna of an exposure system, were exposed to a 1439 MHz field for one hour a day. The rats in EM(-) group were also in the exposure system, however, without high-frequency electromagnetic wave (HF-EMW) exposure. The animals in the control group were neither placed in the system nor exposed to HF-EMWs. The exposure period was two or four weeks. The energy dose rate peaked at 2 W/kg in the brain; the average over the whole body was 0.25 W/kg. The changes in the permeability of BBB were investigated by Evans blue injection method and by immunostaining of serum albumin. HF-EMWs had no effect on the permeability of BBB. The morphological changes in the cerebellum were investigated by assessing the degeneration of Purkinje cells and the cell concentration in the granular layer. No significant changes were observed in the groups of rats exposed to HF-EMWs for two or four weeks. Averaged body masses were not affected by HF-EMWs exposure. In conclusion, a 1439 MHz TDMA field did not induce observable changes in the permeability of the BBB, morphological changes in the cerebellums, or body mass changes in rats, as evaluated by the conventional methods.
我们研究了暴露于手机所使用的1439兆赫时分多址（TDMA）场对血脑屏障（BBB）通透性、大脑形态变化以及体重波动的影响。将雄性斯普拉格-道利（SD）大鼠分为三组，每组八只。EM(+)组的大鼠头部环绕暴露系统的中央天线排列成一圈，每天暴露于1439兆赫场一小时。EM(-)组的大鼠也处于暴露系统中，但未暴露于高频电磁波（HF-EMW）。对照组的动物既未置于该系统中，也未暴露于HF-EMW。暴露期为两周或四周。大脑中的能量剂量率峰值为2瓦/千克；全身平均为0.25瓦/千克。通过伊文思蓝注射法和血清白蛋白免疫染色研究BBB通透性的变化。HF-EMW对BBB通透性没有影响。通过评估浦肯野细胞的退化和颗粒层中的细胞浓度来研究小脑的形态变化。在暴露于HF-EMW两周或四周的大鼠组中未观察到显著变化。平均体重不受HF-EMW暴露的影响。总之，通过传统方法评估，1439兆赫TDMA场未在大鼠的BBB通透性、小脑形态变化或体重变化方面引起可观察到的变化。
