硝唑咪显著延长皮肤同种异体移植存活时间。首例报告。
Marked prolongation of skin homograft survival with niridazole. A first report.
作者信息
Mandel M A, Mahmoud A A, Warren K S
出版信息
Plast Reconstr Surg. 1975 Jan;55(1):76-89. doi: 10.1097/00006534-197501000-00012.
Abstract
Niridazole, a nitroheterocyclic drug used to treat helminth infections is reported for the first time to suppress cell-mediated immunity, as ascertained by multiple in vivo assays. Skin homograft survival time was significantly prolonged in mice, without loss of animals due to drug toxicity.
摘要
硝唑尼特，一种用于治疗蠕虫感染的硝基杂环药物，首次被报道可抑制细胞介导的免疫，这是通过多种体内试验确定的。小鼠皮肤同种异体移植存活时间显著延长，且无动物因药物毒性死亡。
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