Salaman J R, Bird M, Godfrey A M, Jones B, Millar D, Miller J
Transplantation. 1977 Jan;23(1):29-32. doi: 10.1097/00007890-197701000-00005.
The immunosuppressive properties of niridazole, an antihelminthic drug, have been investigated in rats. When given orally in a dose of 50 mg/kg, it extended the median survival of cardiac allografts from 7 to 20 days. The immunosuppressive effect was not increased by giving either azathioprine or prednisolone concurrently but when all three drugs were combined, immunosuppression was profound and only two of eight grafts were rejected. Drug combinations incorporating niridazole at a lower dosage or for a shorter period were less effective, and azathioprine and prednisolone on their own or used together prolonged graft survival only marginally in this model. It is concluded that niridazole is a powerful immunosuppressive drug in this species and a synergistic effect can be obtained by using it in combination with azathioprine and prednisolone.
抗蠕虫药硝唑咪的免疫抑制特性已在大鼠中进行了研究。当以50毫克/千克的剂量口服时，它将心脏同种异体移植的中位存活时间从7天延长至20天。同时给予硫唑嘌呤或泼尼松龙并不会增强免疫抑制效果，但当三种药物联合使用时，免疫抑制作用显著，8个移植物中只有2个被排斥。以较低剂量或较短时间使用含硝唑咪的药物组合效果较差，在该模型中，硫唑嘌呤和泼尼松龙单独使用或联合使用仅能略微延长移植物存活时间。结论是，硝唑咪在该物种中是一种强效免疫抑制药物，将其与硫唑嘌呤和泼尼松龙联合使用可产生协同效应。
