Martinez A, Esteban A, Castro A, Gil C, Conde S, Andrei G, Snoeck R, Balzarini J, De Clercq E
Instituto de Quimica Medica (CSIC), Madrid, Spain.
Antivir Chem Chemother. 2000 May;11(3):221-30. doi: 10.1177/095632020001100305.
The synthesis of acyclonucleosides derived from thieno[3,2-c] and thieno[2,3-c][1,2,6]thiadiazine 2,2-dioxides was achieved following the silylation method. Lipase-mediated methodology was employed for deprotection of the acyclic moieties. The antiviral effects were determined against a broad spectrum of viruses, including cytomegalovirus (CMV) and varicella zoster virus (VZV). Only minor antiviral activity against VZV was observed for those acyclonucleosides carrying a benzyl group.
通过硅烷化方法实现了源自噻吩并[3,2 - c]和噻吩并[2,3 - c][1,2,6]噻二嗪2,2 - 二氧化物的无环核苷的合成。采用脂肪酶介导的方法对无环部分进行脱保护。针对包括巨细胞病毒（CMV）和水痘带状疱疹病毒（VZV）在内的多种病毒测定了抗病毒效果。对于那些带有苄基的无环核苷，仅观察到对VZV的轻微抗病毒活性。
