分离的灵长类动物胃黏膜的酸分泌
Acid secretion by isolated primate gastric mucosa.
作者信息
Rangachari P K
出版信息
Am J Physiol. 1979 Jun;236(6):E733-7. doi: 10.1152/ajpendo.1979.236.6.E733.
Pentagastrin, histamine, and acetylcholine stimulated acid secretion in the isolated rhesus (Macaca mulatta) gastric mucosa. The potencies were in the order pentagastrin greater than histamine greater than acetylcholine. However, histamine was more effective, the calculated maximal response being twice as great as for the other two agonists. Metiamide inhibited acid secretion induced by both histamine and pentagastrin. Whereas the inhibition of histamine by metiamide was surmountable, that of pentagastrin was not. Atropine inhibited the response to acetylcholine. Even in higher doses, atropine had no effect on histamine. With stimulation, transmucosal potential differences and resistances decreased; the changes were reversed on inhibition.
五肽胃泌素、组胺和乙酰胆碱可刺激恒河猴离体胃黏膜的胃酸分泌。其效力顺序为五肽胃泌素＞组胺＞乙酰胆碱。然而，组胺的作用更有效，计算得出的最大反应是其他两种激动剂的两倍。甲硫咪胺抑制组胺和五肽胃泌素诱导的胃酸分泌。甲硫咪胺对组胺的抑制作用是可克服的，而对五肽胃泌素的抑制作用则不可克服。阿托品抑制对乙酰胆碱的反应。即使使用更高剂量，阿托品对组胺也没有影响。刺激时，跨黏膜电位差和电阻降低；抑制时这些变化则逆转。
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