Steiner P, Rao M, Victoria M S, James P, Steiner M
Am Rev Respir Dis. 1979 Apr;119(4):680-2. doi: 10.1164/arrd.1979.119.4.680.
A continuing study of the frequency of primary drug resistance among children treated at the Kings County Hospital Center of Brooklyn during the years 1973 through 1977 showed a high incidence of primary drug resistance to isoniazid (8.8 per cent) and to streptomycin (12.3 per cent). In contrast, there were no strains resistant to cycloserine, viomycin, ethambutol, or rifampin, and only one of 57 strains (1.8 per cent) was resistant to ethionamide, and one (1.8 per cent) was resistant to para-aminosalicylic acid. Comparison with previous studies begun in 1961 showed no significant increase in resistance to isoniazid during 3 prior periods of study and no increase in resistance to streptomycin during the last 2 periods of study. It must be emphasized that these findings relate only to the children of a local community, and do not reflect the prevalence of primary drug resistance elsewhere in this country or among different age groups.
一项对1973年至1977年期间在布鲁克林国王郡医院中心接受治疗的儿童原发性耐药频率的持续研究表明，对异烟肼的原发性耐药发生率很高（8.8%），对链霉素的原发性耐药发生率也很高（12.3%）。相比之下，没有对环丝氨酸、紫霉素、乙胺丁醇或利福平耐药的菌株，57株菌株中只有1株（1.8%）对乙硫异烟胺耐药，1株（1.8%）对对氨基水杨酸耐药。与1961年开始的先前研究相比，在之前的3个研究阶段中，对异烟肼的耐药性没有显著增加，在最后2个研究阶段中，对链霉素的耐药性也没有增加。必须强调的是，这些发现仅与当地社区的儿童有关，并不反映该国其他地区或不同年龄组中原发性耐药的流行情况。
