Jou H J, Shyu M K, Shih J C, Chang M Y, Lim C C, Tzeng C Y, Chen S M, Hsieh F J
Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei.
J Matern Fetal Med. 2000 Mar-Apr;9(2):118-21. doi: 10.1002/(SICI)1520-6661(200003/04)9:2<118::AID-MFM6>3.0.CO;2-C.
To establish normative data of maternal serum chorionic gonadotropin (hCG) during the second trimester in an Asian population.
We measured the maternal serum hCG levels in 17,955 normal singleton pregnancies between 15 and 21 weeks of gestation. The gestation age was estimated by measurement of fetal biparietal distance (BPD) in all cases. Median values of hCG at various gestational weeks were calculated and the values of hCG were converted to multiple of median (MoM). The incidences of low MoM value and high MoM value were also calculated.
The mean and median values of hCG were 57,153 mIU/ml and 50,120 mIU/ml, respectively, at 15 weeks of gestation and then decreased to 30,898 mIU/ml and 26,226 mIU/ml, respectively, at 21 weeks. We found 8.6% and 9.4% of normal singleton pregnancies have hCG MoM values >2.0 MoM and <0.5 MoM, respectively.
Our report provides a normal reference data of second trimester maternal hCG levels by ultrasound dating in an Asian population.
建立亚洲人群孕中期母血清绒毛膜促性腺激素（hCG）的规范数据。
我们测量了17955例孕15至21周的正常单胎妊娠孕妇的母血清hCG水平。所有病例均通过测量胎儿双顶径（BPD）来估计孕周。计算不同孕周hCG的中位数，并将hCG值转换为中位数倍数（MoM）。还计算了低MoM值和高MoM值的发生率。
孕15周时hCG的均值和中位数分别为57153 mIU/ml和50120 mIU/ml，到孕21周时分别降至30898 mIU/ml和26226 mIU/ml。我们发现分别有8.6%和9.4%的正常单胎妊娠孕妇的hCG MoM值>2.0 MoM和<0.5 MoM。
我们的报告提供了亚洲人群通过超声确定孕周的孕中期母血清hCG水平的正常参考数据。
