Gotter A L, Manganaro T, Weaver D R, Kolakowski L F, Possidente B, Sriram S, MacLaughlin D T, Reppert S M
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nat Neurosci. 2000 Aug;3(8):755-6. doi: 10.1038/77653.
The timeless (tim) gene is essential for circadian clock function in Drosophila melanogaster. A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function.
无时间基因（tim）对于黑腹果蝇的昼夜节律钟功能至关重要。一种假定的小鼠同源基因，即小鼠无时间基因（mTim），一直难以在哺乳动物的昼夜节律钟中定位。在此我们表明，mTim对胚胎发育至关重要，但并未证实其具有昼夜节律功能。
