中华蟾蜍卵母细胞中的核成熟抑制剂

Nuclear maturation inhibitors in Bufo arenarum oocytes.

作者信息

de Romero I R, de Atenor M B, Legname A H

机构信息

Instituto de Biología, Universidad Nacional de Tucumán, CONICET, S. M. de Tucumán, Argentina.

出版信息

Biocell. 1998 Apr;22(1):27-34.

PMID:10904524

Abstract

In Bufo arenarum, as in other amphibian species, nuclear maturation--characterized by germinal vesicle breakdown (GVBD) and meiosis resumption--is induced by progesterone. Seasonal variations in the sensitivity to progesterone were observed in Bufo arenarum oocytes. The gonadotropin FSH and drugs such as dbcAMP and xanthine did not affect nuclear maturation per se, although they acted as negative modulators of progesterone-induced nuclear maturation. Similar results to FSH in nuclear maturation were obtained with 17 beta-estradiol.

摘要

在南美蟾蜍（Bufo arenarum）中，与其他两栖类物种一样，核成熟——以生发泡破裂（GVBD）和减数分裂恢复为特征——是由孕酮诱导的。在南美蟾蜍卵母细胞中观察到了对孕酮敏感性的季节性变化。促性腺激素FSH以及诸如二丁酰环磷腺苷（dbcAMP）和黄嘌呤等药物本身并不影响核成熟，尽管它们作为孕酮诱导的核成熟的负调节剂发挥作用。在核成熟方面，17β-雌二醇获得了与FSH相似的结果。