Sinsawaiwong S, Phanthumchinda K, Jongpiputvanich S
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1997 Oct;80(10):667-70.
A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine. Elevation of muscle enzymes and electromyography were compatible with myopathy. Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy. The clinical improvement and decreasing in muscle enzyme level occurred after colchicine withdrawal. Other potential causes of myopathy such as chronic renal failure and other drugs were ruled out. We suggested that colchicine should be used with caution in the presence of renal failure especially when other drugs which affect the metabolism of colchicine are also prescribed.
一名60岁的慢性肾衰竭女性在接受常规剂量秋水仙碱治疗后出现急性近端肌无力。肌酶升高和肌电图检查结果符合肌病表现。肌肉活检显示肌纤维大小不一，有少量空泡化纤维，这些都是秋水仙碱诱发肌病的特征。停用秋水仙碱后临床症状改善，肌酶水平下降。排除了其他可能导致肌病的原因，如慢性肾衰竭和其他药物。我们建议，在存在肾衰竭的情况下，尤其是同时开具了其他影响秋水仙碱代谢的药物时，应谨慎使用秋水仙碱。
