Tan K H, Cotterrell D, Sykes K, Sissons G R, de Cossart L, Edwards P R
Department of Vascular Surgery, Countess of Chester Hospital, U.K.
Eur J Vasc Endovasc Surg. 2000 Jul;20(1):72-8. doi: 10.1053/ejvs.2000.1137.
Exercise training improves the walking distance of claudicants. The aim of this study was to investigate factors associated with the improvement in the maximum walking distance (MWD) in respect to cardiovascular, respiratory and metabolic adaptations.
Forty claudicants were studied. Common femoral artery blood flow (BF), heart rate (HR), oxygen consumption (VO(2)), respiratory exchange ratio (RER), lactate levels, blood rheology and lipid profiles were measured. Tests were repeated after 3 months of exercise training.
Fifteen patients did not complete the exercise program. For patients who did complete the program, MWD improved by 82%. A significant reduction in HR and VO(2)during exercise was demonstrated. No significant changes occurred in BF or RER. Although MWD increased significantly, there was no increase in recovery VO(2)(oxygen debt). A significant reduction in post-exercise lactate levels occurred. Blood rheology was unchanged, but an improvement in HDL levels was noted.
Many claudicants could not complete an exercise program, mainly due to osteoarthritis. Exercise training improved exercise tolerance significantly without any increase in BF. The HR and oxygen cost of similar exercise was reduced. An improved MWD did not correlate with a higher oxygen debt or lactate load. Favourable changes in lipid profiles occurred.
运动训练可提高间歇性跛行患者的步行距离。本研究旨在探讨与最大步行距离（MWD）改善相关的心血管、呼吸和代谢适应因素。
对40名间歇性跛行患者进行研究。测量股总动脉血流量（BF）、心率（HR）、耗氧量（VO₂）、呼吸交换率（RER）、乳酸水平、血液流变学和血脂谱。运动训练3个月后重复进行测试。
15名患者未完成运动计划。对于完成运动计划的患者，MWD提高了82%。运动期间HR和VO₂显著降低。BF或RER无显著变化。尽管MWD显著增加，但恢复VO₂（氧债）并未增加。运动后乳酸水平显著降低。血液流变学无变化，但高密度脂蛋白水平有所改善。
许多间歇性跛行患者无法完成运动计划，主要原因是骨关节炎。运动训练显著提高了运动耐力，而BF没有增加。相似运动的HR和氧耗降低。MWD的改善与更高的氧债或乳酸负荷无关。血脂谱发生了有利变化。
