Anderson L C, Nordling S, Häyry P
J Immunol. 1975 Apr;114(4):1226-9.
Guinea pig lymph node and blood lymphocytes have been physically fractionated in preparative cell electrophoresis into two functionally viable populations, the high mobility cell population (HMC) and the low mobility cell population (LMC). By using cell surface markers and functional tests known to be specific for T and B lymphocytes, respectively, it is shown that the T lymphocytes localize in the HMC population and the B lymphocytes in the LMC population. The spleen lymphocytes do not separate into the two populations. They move into one single broad peak containing both T and B cells. This finding indicates the presence of electrokinetically different subsets of T and B lymphocytes in the spleen on one hand and in the lymph node and blood on the other hand.
豚鼠的淋巴结和血液淋巴细胞已通过制备性细胞电泳进行了物理分离，分成两个功能上具有活性的群体，即高迁移率细胞群体（HMC）和低迁移率细胞群体（LMC）。通过分别使用已知对T淋巴细胞和B淋巴细胞具有特异性的细胞表面标志物和功能测试，结果表明T淋巴细胞定位于HMC群体中，而B淋巴细胞定位于LMC群体中。脾淋巴细胞不会分离成这两个群体。它们移动到一个包含T细胞和B细胞的单一宽峰中。这一发现表明，一方面脾脏中存在电泳性质不同的T淋巴细胞和B淋巴细胞亚群，另一方面淋巴结和血液中也存在。
