Moore T C, Vigran T S, Lemmi C A
J Thorac Cardiovasc Surg. 1975 Mar;69(3):402-6.
The accumulation of 131I hippurate in heterotopic (abdominal) rat heart allografts (Brown-Norway to Lewis) in comparison with native (autologous) hearts 6 and 7 days after transplantation was studied by noninvasive scintigraphic imaging and by direct isotope counting of excised hearts. Six hours after intravenous isotope injection, isotope accumulation in the allografted heart was clearly identified by scintigraphic study in comparison with the background, kidneys, urinary bladder, and native heart. Six and 7 days after transplantation, excised allografted hearts were significantly increased in weight in comparison with native hearts. A significant increase in isotope accumulation in allografted hearts in comparison with native hearts was found both per heart and per gram of heart. The findings of this study suggests the potential usefulness of 131I hippurate in the immunoinflammatory monitoring of organ allograft rejection by direct counting as well as by noninvasive scintigraphic study if sufficient time is allowed to permit clearance of high concentrations of isotope from the background areas, kidneys, and urinary bladder.
通过非侵入性闪烁成像以及对切除心脏进行直接同位素计数，研究了移植后6天和7天异位（腹部）大鼠心脏同种异体移植物（从布朗 - 挪威大鼠到刘易斯大鼠）中碘[131I]马尿酸盐的蓄积情况，并与天然（自体）心脏进行了比较。静脉注射同位素6小时后，与背景、肾脏、膀胱和天然心脏相比，闪烁成像研究清楚地确定了同种异体移植心脏中的同位素蓄积情况。移植后6天和7天，与天然心脏相比，切除的同种异体移植心脏重量显著增加。无论是按每颗心脏还是按每克心脏计算，与天然心脏相比，同种异体移植心脏中的同位素蓄积均显著增加。本研究结果表明，如果有足够时间使背景区域、肾脏和膀胱中高浓度的同位素清除，碘[131I]马尿酸盐通过直接计数以及非侵入性闪烁成像研究在器官同种异体移植排斥反应的免疫炎症监测中具有潜在用途。
