Hoerl H D, Schink J, Hartenbach E, Wagner J L, Kurtycz D F
Department of Pathology, University of Wisconsin Medical School, Madison, USA.
Diagn Cytopathol. 2000 Jul;23(1):14-8. doi: 10.1002/1097-0339(200007)23:1<14::AID-DC3>3.0.CO;2-S.
Poorly differentiated neuroendocrine (small-cell) carcinoma of cervical origin is a rare neoplasm that frequently metastasizes. Although the cytologic features have been described for conventional cervical smears, we know of no reports of its appearance in ThinPrep (TP) material. Therefore, we present a TP case of primary, small-cell carcinoma arising in a 46-yr-old female, confirmed by histologic and immunohistochemical analysis. Similar to conventional smears, the neoplastic cells occurred either individually or in small clusters. The cells were relatively monomorphic, with stippled chromatin and minimal amounts of cytoplasm. Unlike conventional smears, nuclear molding was not prominent (although overlap was observed), and nuclear smearing was not identified. The features are compared to TP cases of squamous-cell carcinoma, small-cell type, and endometrioid adenocarcinoma, which are close mimics of small-cell carcinoma. We conclude that correct diagnosis of small-cell carcinoma in TP is difficult, requiring a high degree of suspicion and immunohistochemical confirmation.
宫颈来源的低分化神经内分泌（小细胞）癌是一种罕见的肿瘤，常发生转移。虽然传统宫颈涂片的细胞学特征已有描述，但我们尚未发现其在ThinPrep（TP）材料中表现的相关报道。因此，我们报告一例46岁女性原发性小细胞癌的TP病例，经组织学和免疫组化分析确诊。与传统涂片相似，肿瘤细胞单个或小簇状出现。细胞相对单一形态，有斑点状染色质，胞质极少。与传统涂片不同的是，核塑型不明显（尽管观察到有重叠），且未发现核涂片现象。将这些特征与鳞状细胞癌小细胞型和子宫内膜样腺癌的TP病例进行比较，这些病例与小细胞癌极为相似。我们得出结论，TP中小细胞癌的正确诊断困难，需要高度怀疑并进行免疫组化确认。
