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cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation.环磷酸腺苷（cAMP）依赖性蛋白激酶通过直接使受体磷酸化来抑制代谢型谷氨酸受体2（mGluR2）与G蛋白的偶联。
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GABA activity mediating cytosolic Ca2+ rises in developing neurons is modulated by cAMP-dependent signal transduction.在发育中的神经元中，介导胞质Ca2+升高的GABA活性受cAMP依赖的信号转导调节。
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本文引用的文献

1
Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.突触前代谢型谷氨酸受体信号传导对钙调蛋白的依赖性。
Science. 1999 Nov 5;286(5442):1180-4. doi: 10.1126/science.286.5442.1180.
2
A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7.蛋白激酶C磷酸化与钙调蛋白结合至代谢型谷氨酸受体7亚型之间的关系。
J Biol Chem. 1999 Sep 24;274(39):27573-7. doi: 10.1074/jbc.274.39.27573.
3
New perspectives for the development of selective metabotropic glutamate receptor ligands.选择性代谢型谷氨酸受体配体开发的新视角。
Eur J Pharmacol. 1999 Jun 30;375(1-3):277-94. doi: 10.1016/s0014-2999(99)00258-7.
4
Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins.蛋白激酶C的激活会破坏II组和III组代谢型谷氨酸受体介导的突触前抑制，并使该受体与GTP结合蛋白解偶联。
Ann N Y Acad Sci. 1999 Apr 30;868:554-7. doi: 10.1111/j.1749-6632.1999.tb11327.x.
5
Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.N-甲基-D-天冬氨酸（NMDA）受体的激活可逆转天然和重组系统中代谢型谷氨酸受体5（mGluR5）的脱敏作用。
Nat Neurosci. 1999 Mar;2(3):234-40. doi: 10.1038/6338.
6
Activation of mGluRII induces LTD via activation of protein kinase A and protein kinase C in the dentate gyrus of the hippocampus in vitro.在体外实验中，代谢型谷氨酸受体II（mGluRII）的激活通过蛋白激酶A和蛋白激酶C的激活在海马齿状回诱导长时程抑制（LTD）。
Neuropharmacology. 1999 Jan;38(1):73-83. doi: 10.1016/s0028-3908(98)00168-3.
7
The glutamate receptor ion channels.谷氨酸受体离子通道
Pharmacol Rev. 1999 Mar;51(1):7-61.
8
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity.代谢型谷氨酸受体：电生理特性及其在可塑性中的作用
Brain Res Brain Res Rev. 1999 Jan;29(1):83-120. doi: 10.1016/s0165-0173(98)00050-2.
9
(S)-4C3HPG reduces infarct size after focal cerebral ischemia.（S）-4C3HPG可减小局灶性脑缺血后的梗死面积。
Neuropharmacology. 1998 Dec;37(12):1649-52. doi: 10.1016/s0028-3908(98)00146-4.
10
Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV.II 型代谢型谷氨酸受体激动剂LY354740和DCG-IV的突触前抑制作用
Eur J Pharmacol. 1998 Sep 4;356(2-3):149-57. doi: 10.1016/s0014-2999(98)00526-3.

环磷酸腺苷（cAMP）依赖性蛋白激酶通过直接使受体磷酸化来抑制代谢型谷氨酸受体2（mGluR2）与G蛋白的偶联。

cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation.

作者信息

Schaffhauser H, Cai Z, Hubalek F, Macek T A, Pohl J, Murphy T J, Conn P J

机构信息

Department of Pharmacology, Program in Molecular Therapeutics and Toxicology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322-3090, USA.

出版信息

J Neurosci. 2000 Aug 1;20(15):5663-70. doi: 10.1523/JNEUROSCI.20-15-05663.2000.

DOI:10.1523/JNEUROSCI.20-15-05663.2000
PMID:10908604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6772548/
Abstract

One of the primary physiological roles of group II and group III metabotropic glutamate receptors (mGluRs) is to presynaptically reduce synaptic transmission at glutamatergic synapses. Interestingly, previous studies suggest that presynaptic mGluRs are tightly regulated by protein kinases. cAMP analogs and the adenylyl cyclase activator forskolin inhibit the function of presynaptic group II mGluRs in area CA3 of the hippocampus. We now report that forskolin has a similar inhibitory effect on putative mGluR2-mediated responses at the medial perforant path synapse and that this effect of forskolin is blocked by a selective inhibitor of cAMP-dependent protein kinase (PKA). A series of biochemical and molecular studies was used to determine the precise mechanism by which PKA inhibits mGluR2 function. Our studies reveal that PKA directly phosphorylates mGluR2 at a single serine residue (Ser(843)) on the C-terminal tail region of the receptor. Site-directed mutagenesis combined with biochemical measures of mGluR2 function reveal that phosphorylation of this site inhibits coupling of mGluR2 from GTP-binding proteins

摘要

II 组和 III 组代谢型谷氨酸受体（mGluRs）的主要生理作用之一是在突触前减少谷氨酸能突触处的突触传递。有趣的是，先前的研究表明，突触前 mGluRs 受到蛋白激酶的严格调控。环磷酸腺苷（cAMP）类似物和腺苷酸环化酶激活剂福斯可林抑制海马体 CA3 区突触前 II 组 mGluRs 的功能。我们现在报告，福斯可林对内侧穿通通路突触处假定的 mGluR2 介导的反应具有类似的抑制作用，并且福斯可林的这种作用被 cAMP 依赖性蛋白激酶（PKA）的选择性抑制剂阻断。一系列生化和分子研究用于确定 PKA 抑制 mGluR2 功能的精确机制。我们的研究表明，PKA 直接在受体 C 末端尾部区域的单个丝氨酸残基（Ser(843)）处使 mGluR2 磷酸化。定点诱变结合 mGluR2 功能的生化测量表明，该位点的磷酸化抑制 mGluR2 与 GTP 结合蛋白的偶联