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听神经瘤——治疗方式。手术、伽玛刀还是观察?

Acoustic neuroma--treatment modalities. Surgery, gamma-knife or observation?

作者信息

Møller P, Myrseth E, Pedersen P H, Larsen J L, Krakenes J, Moen G

机构信息

Department of Otolaryngology, Head and Neck Surgery, Haukeland Hospital, University of Bergen, Norway.

出版信息

Acta Otolaryngol Suppl. 2000;543:34-7.

Abstract

We present our results of 211 patients with acoustic neuroma over a period of 10 years, 1988-97. We operated on 100 and 111 had Gamma-knife (GK) treatment (69 were available to follow-up). The results are excellent for surgery on small and intracanalicular tumours. In tumours of the same size, surgery and GK treatment give comparable, but somewhat different, results. In the GK group of 54 primary treated patients, 3 patients had to be operated on and another 4 developed hydrocephalus. A group of 35 acoustic tumours was observed for more than 3 years. Nineteen did grow (54%). Hearing was unchanged in 23%. We performed surgery in 11 patients and gave 2 patients GK treatment because of tumour growth of > 2 mm in diameter a year. We conclude that either treatment is effective for small and medium-sized acoustic neuromas. Hearing preservation was best in the GK-treated group (80%), compared to only 12.5% in the group operated via the suboccipital route. Larger tumours and most medium-sized tumours should be operated, as should smaller tumours with persistent symptoms of vertigo and pain. Medical contraindications to surgery or reluctance to undergo surgery make GK treatment a good alternative. Treatment of residual tumours with the GK could also be a solution to a difficult problem.

摘要

我们展示了1988年至1997年这10年间211例听神经瘤患者的治疗结果。我们对100例患者进行了手术,111例接受了伽玛刀(GK)治疗(其中69例可进行随访)。对于小型和管内型肿瘤,手术效果极佳。对于相同大小的肿瘤,手术和GK治疗的结果相当,但也有所不同。在54例初次接受GK治疗的患者组中,有3例患者不得不接受手术,另有4例出现脑积水。一组35例听神经瘤患者被观察了3年以上。19例肿瘤生长(54%)。23%的患者听力未变。由于肿瘤每年直径增长>2mm,我们对11例患者进行了手术,并对2例患者进行了GK治疗。我们得出结论,两种治疗方法对中小型听神经瘤均有效。GK治疗组的听力保留情况最佳(80%),而经枕下途径手术的组仅为12.5%。较大的肿瘤和大多数中型肿瘤应进行手术,有持续眩晕和疼痛症状的较小肿瘤也应如此。手术的医学禁忌症或不愿接受手术使得GK治疗成为一个很好的选择。用GK治疗残留肿瘤也可能是解决难题的一个办法。

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