Austin J, Hoogendoorn B, Buckland P, Jones I, McCandless F, Williams N, Middle F, Owen M J, Craddock N, O'Donovan M C
Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Psychiatr Genet. 2000 Mar;10(1):51-4. doi: 10.1097/00041444-200010010-00009.
Neurotensin (NT) localizes within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems, and it is now clear that NT can selectively modulate dopaminergic neurotransmission. It has therefore been proposed that altered NT function might contribute to the pathogenesis of neuropsychiatric disorders in which disordered dopaminergic neurotransmission is suspected. We have previously screened the gene encoding NT in a sample of schizophrenic and bipolar subjects, and identified three sequence variants. These have now been tested for association with bipolar disorder using a case-control sample of unrelated bipolar subjects and matched controls. No evidence for association was found, and our data therefore suggest that sequence variation in this gene does not make an important contribution to susceptibility to bipolar disorder.
神经降压素（NT）定位于中皮层、中边缘和黑质纹状体系统的多巴胺能神经元内，目前很清楚的是，NT可选择性调节多巴胺能神经传递。因此，有人提出NT功能改变可能导致那些怀疑存在多巴胺能神经传递紊乱的神经精神疾病的发病机制。我们之前在一组精神分裂症和双相情感障碍患者样本中筛查了编码NT的基因，并鉴定出三个序列变异。现在我们使用一组不相关的双相情感障碍患者病例对照样本及匹配的对照，对这些变异进行了双相情感障碍的关联测试。未发现关联证据，因此我们的数据表明该基因的序列变异对双相情感障碍易感性没有重要影响。
