Parkinson C, Trainer P J
Department of Endocrinology, Christie Hospital, Manchester, UK.
Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Oct;13(3):419-30. doi: 10.1053/beem.1999.0032.
Knowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and is not dependent on tumour characteristics. This chapter reviews the interaction between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.
对生长激素（GH）与生长激素受体（GHR）之间相互作用的了解，促成了生长激素受体拮抗剂的合理设计。一种能够在细胞水平阻断生长激素作用的生长激素类似物，与目前的医学疗法相比，具有更高的作用特异性，且不依赖于肿瘤特征。本章回顾了生长激素与生长激素受体之间的相互作用，并讨论了肢端肥大症中生长激素受体拮抗剂治疗方面的突出问题。
