Cornelisse C J, Schott H C, Olivier N B, Mullaney T P, Koller A, Wilson D V, Derksen F J
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314, USA.
J Am Vet Med Assoc. 2000 Jul 15;217(2):231-5. doi: 10.2460/javma.2000.217.231.
An 18-year-old Thoroughbred gelding was evaluated because of sudden onset of ventricular tachycardia and signs of colic. Three years earlier, a diastolic decrescendo murmur, consistent with aortic regurgitation, had been detected, but the horse continued to perform well and compete successfully. Cardiac ultrasonographic examination revealed a defect in the interventricular septum below the aortic root, and serum concentrations of cardiac troponin I (cTnI) were higher than those measured in clinically normal horses. Repeated development of tachyarrhythmia during hospitalization prompted a decision to euthanatize the horse. A ruptured endocardial jet lesion below the aortic valve with formation of a cleft into the interventricular septum was found on necropsy. This report of increased serum cTnI concentrations in a horse with myocardial disease and our other findings suggest that assessment of cardiac troponin concentrations may be a useful tool in the evaluation of horses with suspected myocardial disease.
一匹18岁的纯种马因突然出现室性心动过速和腹痛症状而接受评估。三年前，检测到一个与主动脉瓣关闭不全相符的舒张期递减型杂音，但这匹马继续表现良好并成功参赛。心脏超声检查显示主动脉根部下方的室间隔有缺损，且血清心肌肌钙蛋白I（cTnI）浓度高于临床正常马匹的测量值。住院期间反复出现快速性心律失常促使决定对这匹马实施安乐死。尸检发现主动脉瓣下方的心内膜喷射性病变破裂，并形成了一个进入室间隔的裂隙。这例患有心肌疾病的马血清cTnI浓度升高的报告以及我们的其他发现表明，评估心肌肌钙蛋白浓度可能是评估疑似患有心肌疾病马匹的一个有用工具。
