Levy Y, Paster E, Dankner G, Ben-Amotz A, Brook J G
Medical Dept. D, Rambam Medical Center, Haifa.
Harefuah. 1998 Mar 15;134(6):449-51, 503, 502.
16 patients with hypercholesterolemia were treated with an extract of alpha-alpha leaves (esterol) while on a low-fat, low-cholesterol diet. Esterol is believed to inhibit the absorption of cholesterol and bile acids and may interfere with the absorption of essential nutrients. As oxidative modification of lipoproteins is required for the process of atherosclerosis, plasma antioxidant vitamins were followed. After 4 months of treatment, plasma cholesterol decreased by 10% from 282 to 250 mg/dl (p < 0.001) and LDL cholesterol by 13%, from 203 to 177 mg/dl (p < 0.001). Plasma antioxidant vitamins E, A and beta-carotene were unchanged. Thus, esterol has a cholesterol-lowering effect but apparently does not lower fat-soluble, plasma antioxidant vitamins. Both cholesterol-lowering and plasma antioxidant vitamins are important for the primary prevention of coronary artery disease in hypercholesterolemia.
16名高胆固醇血症患者在低脂、低胆固醇饮食的同时，接受了α-α叶提取物（艾司特醇）治疗。据信，艾司特醇可抑制胆固醇和胆汁酸的吸收，可能会干扰必需营养素的吸收。由于动脉粥样硬化过程需要脂蛋白的氧化修饰，因此对血浆抗氧化维生素进行了跟踪监测。治疗4个月后，血浆胆固醇从282mg/dl降至250mg/dl，下降了10%（p<0.001），低密度脂蛋白胆固醇从203mg/dl降至177mg/dl，下降了13%（p<0.001）。血浆抗氧化维生素E、A和β-胡萝卜素未发生变化。因此，艾司特醇具有降低胆固醇的作用，但显然不会降低脂溶性血浆抗氧化维生素。降低胆固醇和血浆抗氧化维生素对高胆固醇血症患者冠心病的一级预防均很重要。
